
From a geographic standpoint, Tennessee is specially bordered by eight other states consequently making it a transshipment corridor and destination location for all transportation methods of illegal drugs. These highways transport an extremely large amount of traffic and are a main method of transporting drugs to and through Tennessee. Consequently, the drug situations in the neighboring states have an effect on Tennessee’s drug smuggling, accessibility, and abuse. Tennessee is mainly a "user" and transshipment state, and is not a main source region for any drug except locally grown marijuana.
Mexican smugglers and Mexican DTOs are still playing a growingly dominant role in the importation and distribution of illicit drugs within North Carolina. Mexican poly-drug organizations are the biggest foreign threat in Tennessee, mainly smuggling in cocaine, meth, marijuana, and heroin.
Marijuana abuse and smuggling is a severe issue throughout Tennessee, particularly in rural regions. Tennessee is a main distributor of locally grown marijuana, although Mexican marijuana has an elevating presence. According to the Appalachia HIDTA Threat Assessment, Tennessee is steadily ranked as one of the top ten states for the eradication of marijuana plant. In specific regions of Tennessee, marijuana is preferred over other substances of abuse by some individuals. On a federal level, in Tennessee, over 5,000 marijuana plants were eradicated and apprehended. Notably, all law enforcement apprehensions in Tennessee amounted to over 539, 370 plants.
Cocaine is generally shipped to Tennessee in multi-kilogram amounts from cities in western America and from Texas, Illinois, Georgia, and California. Hamilton, Davidson, and Shelby counties are viewed as the distribution hubs for Tennessee. Crack cocaine is favored over the powdered cocaine in Tennessee. Tennessee is still a region of choice for the illegal operations of structured Mexican drug smuggling organizations.

The accessibility and demand for meth is still increasing in Tennessee. A lot of the meth used in Tennessee is shipped from Mexico and from the states along the southwest border. Clandestine meth labs can be encountered everywhere in Tennessee, but are mainly situated in the Appalachian regions in Eastern Tennessee. The amounts of meth clandestine lab apprehensions and meth drug apprehensions have grown significantly over the past year. This growth is in spite of the legislation passed in 2005 banning the accessibility of precursors—a necessity for processing meth. In 2008, over 600 labs apprehensions occurred, as opposed to 539 in 2007. The labs that are encountered in Tennessee are typically viewed as small and unsophisticated.
These labs are still a substantial threat because lab operators are commonly armed and significantly included in meth's distribution and therefore tend to booby trap the sites. Mexican meth smuggling groups dominate a lot of the meth distribution in the Chattanooga region, but command and dominance for these Mexican organizations are regularly detected in Dalton, Georgia. A rise in meth consumption and abuse is expected in Tennessee as the drug gains popularity over crack cocaine consumption. This trend is because of the highly addictive nature of meth, especially Ice.
Heroin consumption in Tennessee is restricted to an extremely small amount of long-time consumers. The heroin smuggling situation has been very consistent in Tennessee for the last several years, though a rise in heroin accessibility and highway interdiction was cited recently.